Functional Analysis of a Migraine-Associated TRESK K+ Channel Mutation
نویسندگان
چکیده
منابع مشابه
Functional analysis of a migraine-associated TRESK K+ channel mutation.
Recent genetic and functional studies suggest that migraine may result from abnormal activities of ion channels and transporters. A frameshift mutation in the human TWIK-related spinal cord K(+) (TRESK) channel has been identified in migraine with aura patients in a large pedigree. In Xenopus oocytes, mutant TRESK subunits exert a dominant-negative effect on whole-cell TRESK currents. However, ...
متن کاملNeurobiology of Disease Functional Analysis of a Migraine-Associated TRESK K Channel Mutation
Recent genetic and functional studies suggest that migraine may result from abnormal activities of ion channels and transporters. A frameshift mutation in the human TWIK-related spinal cord K (TRESK) channel has been identified in migraine with aura patients in a large pedigree. In Xenopus oocytes, mutant TRESK subunits exert a dominant-negative effect on whole-cell TRESK currents. However, que...
متن کاملNon-migraine Associated Tresk K
1 Non-migraine associated TRESK K channel variant C110R does not increase 2 the excitability of trigeminal ganglion neurons 3 4 Authors: 5 Zhaohua Guo, Ping Liu, Fei Ren, and Yu-Qing Cao 6 Affiliation: 7 Washington University Pain Center and Department of Anesthesiology, Washington 8 University School of Medicine, St. Louis, Missouri, USA 9 Running title: 10 TRESK mutation/variant and trigemina...
متن کاملFunctional analysis of missense variants in the TRESK (KCNK18) K+ channel
A loss of function mutation in the TRESK K2P potassium channel (KCNK18), has recently been linked with typical familial migraine with aura. We now report the functional characterisation of additional TRESK channel missense variants identified in unrelated patients. Several variants either had no apparent functional effect, or they caused a reduction in channel activity. However, the C110R varia...
متن کاملModulation of TRESK Background K+ Channel by Membrane Stretch
The two-pore domain K(+) channel TRESK is expressed in dorsal root ganglion and trigeminal sensory neurons where it is a major contributor to background K(+) current. TRESK acts as a break to prevent excessive sensory neuron activation and decreases in its expression or function have been involved in neuronal hyperexcitability after injury/inflammation, migraine or altered sensory perception (t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2013
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1237-13.2013